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Topical corticosteroids can lead to thin skin, red skin lesions and acne. Side effects of injected corticosteroids. Positive and negative effects of steroids on health february 7, 2017 february 16, 2019 sara anabolic , blood cell count , chronic mood swipe , depression , digbestion , digestion , fever , growth hormone , headache , increase protein , mental illness , mental issue , negative effects of steroids , steroid , stomach upset. Steroid injections into a specific area are generally well tolerated and are less likely than other forms of steroid drugs to produce serious side effects. Also, the injections may help avoid the need for oral steroids or increased doses of oral steroids, which could have greater side effects. The positive effects of steroids there are two primary reasons for anabolic steroid use; therapeutic treatment and performance enhancement. 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